Silver (Ag) Nano Powder

General Description
A Silver (Ag) Nanopowder/Nanoparticles versatile substance with pharmacological, anti-microbial, conductive, and chemical applications, silver nanopowder/nanoparticles appear as colored powders available in various granule sizes and coatings. Nanochemazone can provide silver nanopowders ranging from particles of 15nm to particles measured in millimeters, with various treatments and coatings for all your needs.

Silver nanoparticles (AgNPs) have become widely used nanomaterial due to its potential application in biomedical and pharmaceutical areas, as due to their antibacterial property. Even though it has antibacterial activity it also shows toxicity at higher concentrations in humans and other organisms. Taking into consideration the above-mentioned concern, we have performed a comparative antibacterial and hemolytic efficacy of gelatin stabilized/coated AgNPs (G-AgNPs) versus uncoated AgNPs. For G-AgNPs UV–Vis absorption shows λ max at 420–425 nm, FT-IR confirms that the presence of an amide group indicates AgNPs is stabilized/coated inside the gelatin and TEM analysis of G-AgNPs shows average particle size of 4.3 ± 1.3 nm that are monodispersed in nature. AgNPs and G-AgNPs were demonstrated for their antibacterial activity using the good diffusion method, Minimum inhibitory concentration (MIC), Minimum bactericidal concentration (MBC), and antibiofilm assay against 4 clinical pathogens. In addition, we have performed a hemolytic assay on human RBC cells. The results show that biocompatible polymer (Gelatin) coated silver nanoparticle (G-AgNPs) exhibits excellent antibacterial activity as well as a minimal hemolytic effect than uncoated AgNPs. Based on this study, we suggest that G-AgNPs can be used as a promising nanomaterial in pharmaceutical and biomedical applications.

Nanopowders dissolve into a variety of solvents, including water, ethanol, and isopropanol, to produce convenient suspensions. Research continuously reveals new applications of silver nanoparticles in fields including biotech, medicine, electronics, and manufacturing, where it often achieves the same end results as more costly solutions.

Silver Nanopowder/Nanoparticles Properties:

Nanosilver dressings, as well as Nano sliver, the derived solution proved to have anti-inflammatory activity in an animal model, Nano sliver alters the expression of matrix Metallo-properties, Suppresses the expression of tumor necrosis factor (TFN)-, interleukin (IL)-12, and induces apoptosis of inflammatory cell, Silver nanoparticles modulate cytokines involved in wound healing. The result indicates the possibility of achieving scar-less wound healing even though further studies using other animal models are required to confirm this.

Silver (Ag) Nanopowder/Nanoparticles Applications:

Conductive applications: A key ingredient in a number of conductive products, including conductive adhesives, LCD and LED screens, touch screens, and conductive slurries used in microelectronics.
Chemical applications: Silver nanopowder/nanoparticles can be utilized to enhance the efficiency and efficacy of chemical reactions, such as ethylene oxidation. The same factors also make them of use in chemical vapor sensors and other devices.
Optical applications: Silver nanopowders play a crucial role in a number of optical applications. You can see silver nanoparticles in solar cells, medical imaging equipment, optical limiters, spectroscopic equipment, and a host of other technology.

Chemical Method:

Among the existed reported methods, so far, chemical methods are preferred for the preparation of Ag-NPs due to the ease in synthesizing them in solution. Many research groups and academia are using these methods to synthesize Ag-NPs in various sizes and shapes. For example, one research group synthesized monodisperse silver nanocubes by simply reducing Ag(NO3) with ethylene glycol in the presence of polyvinylpyrrolidone (PVP) polymer; the process was called the polyol process.
In this process, it has been revealed that ethylene glycol works as both the solvent and the reducing agent. Furthermore, the size and shape of the nanocubes were dependent on the molar ratio of Ag(NO3) and PVP. Thus by controlling the experimental parameters, the geometry (size and shapes) of the Ag-NPs can be tailored. Round shaped Ag-NPs with controlled size and monodispersity were synthesized by modifying the polyol method using precursor injection. In this method, particles of 20 nm or smaller size were prepared. The governing factors of the precursor injection method were precursor injection rate and in situ conditions (inside the reaction mixture).
Antibacterial Characteristics of Silver Nanoparticles
Silver nanoparticles attracted tremendous interest in the biomedical field, thanks to their attractive and unique Nano-related properties, including their high intrinsic antimicrobial efficiency and non-toxic nature. Among the manifold potential applications of AgNPs in this particular domain, impressive attention and efforts were lately directed toward their promising implications in wound dressing, tissue scaffold, and protective clothing applications. Some essential aspects related to the specific antimicrobial characteristics of AgNPs implies their intrinsic physical and chemical properties, which include maintaining the nanoscale size of AgNPs, improving their dispersion and stability, and avoiding aggregation. There are many studies that experimentally proved that the anti-pathogenic activity of AgNPs is better than that exhibited by silver ions.

A major concern of the worldwide healthcare system is represented by the alarming and emerging phenomenon of pathogenic drug-resistant occurrence. Therefore, AgNPs represent potent candidates for the nanotechnology-derived development of novel and effective biocompatible nanostructured materials for unconventional antimicrobial applications. Thanks to their intrinsic broad bactericidal effects exhibited against both Gram-negative and Gram-positive bacteria and their physicochemical properties, AgNPs are one of the most used metallic nanoparticles in modern antimicrobial applications. Different studies reported that AgNPs interact with the bacterial membrane and penetrate the cell, thus producing a drastic disturbance regarding proper cell function, structural damage, and cell death [56]. We included in Figure 1 distinctive mechanisms described during the interaction of AgNPs with bacterial cells

Silver Nanopowder/Nanoparticles:

Silver is a soft, white, lustrous transition metal possessing high electrical and thermal conductivity. It has been known longer than the recorded history due to its medical and therapeutic benefits before the realization that microbes are agents for infections. It is used in many forms like coins, vessels, solutions, foils, sutures, and colloids as lotions, ointments, and so forth. It is the foremost therapeutic agent in medicine for infectious diseases and surgical infections. The benefits of silver are more than the risk factors

Nanoscience is a new interdisciplinary subject that depends on the fundamental properties of Nanosize objects. Nanoparticles possess wondrous optical, electronic, magnetic, and catalytic properties than the bulk material owing to their high surface area to volume ratio. Metal nanoparticles like silver and gold show different colors due to their Surface Plasmon Resonance (SPR) phenomenon. It is a collective oscillation of free electrons of the metal nanoparticles in resonance with the frequency of the light wave interactions causing the SPR band to appear in the visible and infrared region.

Metallic nanoparticles are produced by various methods, the more common ones being chemical and physical methods. The aforesaid methods produce pure and well-defined nanoparticles, but the chemicals used in the synthesis are toxic, energy-consuming, expensive, and not suitable for biological applications. The syntheses of metal nanoparticles are covered in the past three decades, but research plant extract-based Nano synthesis mushroomed only in the last decade.

Silver nanoparticles have received attention due to their physical, chemical, and biological properties that attributed to the catalytic activity and bactericidal effects and found applications in Nano biotechnological research. They are used as antimicrobial agents in wound dressings, as topical creams to prevent wound infections, and as anticancer agents.

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